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Jeannine M. Durdik Office: SCEN 525 |
Degrees:
Ph.D. Johns Hopkins University, 1981Research Interests:
We have shown that pentoxifylline given during the development of a primary responses enhances the memory responses of T cells. We are currently exploring the mechanism of its activities in lymphocytes.
We are testing the hypothesis that double stranded breaks accumulate in the DNA in older individuals and that this affects the development of lymphocytes in aged animals.
Academic Interests:
Molecular immunology, stability of genes, control of avian and mammalian immune responses.Lab Website:
Click here to go to Dr. Durdik's lab website.Recent Publications:
Mattoo H., Kandpal U., Lewis V., Williams M., George A., Rath S,. Durdik J., Bal V. Naive T cells from aged mice progress poorly to the central memory stage and show increased susceptibility to death upon primary activation. Submitted for publication.
Srivastava S., Banerjee H., Chaudhry A., Khare A., Apurva Sarin A., George A., Bal V., Durdik J. M., Rath S. 2007. Apoptosis-inducing factor (Aif) regulates death in peripheral T cells. J. Immunol. 179: 797-803.
Vig M., Srviastava S., Kandpal U., Sade H., Lewis V., Sarin A., George A., *Durdik J., *Bal V., *Rath S. 2004. Inducible nitric oxide synthase in T cells regulates T cell death and immune memory. [*communicating authors]. J. Clinical Investigation 113: 1734-1740.
Jena P. K., Smith D. A., Zhang X., Aviszus K., Durdik J. M., Wysocki, L. J. 2003. Somatic translocation and differential expression of lg Mu transgene copies implicate a role for the lgh locus in memory B cell development. Molecular Immunology 39:885-897.
Vig M., George A., Sen R., Durdik J. M., Rath S., Bal V. 2002. Commitment of activated T cells to secondary responsiveness is enhanced by signals mediated through cAMP-dependent protein kinase A-1. Molecular Pharmacology 62:1471-1478.